Home Reviews Top 15 Best Dog Anxiety Aids for Calming

Top 15 Best Dog Anxiety Aids for Calming


The reasons for anxiety problems in dogs are varied. Some may just be hyperactive, while others may suffer from excessive fear or worry. Triggers could be anything from other dogs to gun blasts or any number of other stimuli. In here we list five options of best dog anxiety aids that owners have found to be the most effective to relieve anxiety in dogs and calm them down.

Note that this article doesn't replace a consultation with a veterinarian. The best dog anxiety medication (or any other meds) may only be prescribed by a vet after your dog has been examined. All of the dog anxiety aids listed in this article and sold over the counter may be weaker, unregulated supplements. Your vet will always know better.

Top Best Dog Anxiety Medication for Calming DogsAccording to some studies, anxiety in dogs becomes a serious issue and it can manifest itself in many different ways. You may not even be aware that your pet suffers from an anxiety disorder until you must seek help from a professional.

In this article, we'll discuss the importance of dealing with anxiety in dogs, why you must try to calm down your dog and what do experts say about this issue.

We'll also take a look at some of the best dog anxiety medication aids, supplements and other ways of relief stress in dogs. Here's a brief on the top five popular ones:

Dog Anxiety Aid Price Quality Rating
Vetoquinol Zylkene 75mg $$$ A 3.9/5
Particular Paws Dog Calming Aid Time Released $$$ A- 3.8/5
Dog Anxiety Relief $$ B+ 3.6/5
Bach Rescue Remedy $$ B 3.7/5
VetriScience Laboratories Composure $ B- 3.7/5

* Click on the best dog anxiety medication for more information and prices, or scroll down below for more details.

Why dogs may need anxiety medication?

While some dogs experience only short and insignificant bouts of anxiety, others may go through a fairly terrifying experience. There are natural science-based proven ways to calm down a dog before you have to rest to using the best dog anxiety medication. But if that doesn't work, additional help from veterinarians and other experts may be needed.

“Emotional distress is the primary cause of the behaviors seen with separation anxiety. The distress stems from the absence of the animal’s person (or persons) to whom they are most attached,” says Dr. Kelly Ballantyne, DVM of College of Veterinary Medicine (source)

What is the best dog anxiety reliefSymptoms of canine anxiety can include panting, shaking, excessive barking and even aggression. That's when you may need to use calming medicine for dogs or find another way to relax your pet and relief anxiety in the dog to avoid further complications.

Alternative ways to relieving anxiety in dogs may be things like dog anxiety vests or even using essential oils for dogs.

Most of us wouldn't associate things like chewing, aggression or barking with canine anxiety. Often, behaviors like these are considered to be general dog behavior issues that require professional dog training to correct. Unfortunately, dog training alone won't fix the underlying issue, and it may even increase your dog's anxiety.

In certain cases, simply changing some environmental variables may help your dog to relieve anxiety. However, if your pet's case is moderate to severe trying one of these anxiety aids for dogs may be your only option to help him. Again, always check with your veterinarian before starting your dog on dog anxiety treatment.

RELATED: The Best Dog Pain Relief Aids

What's the Best Dog Anxiety Medication?
top 5 anxiety solutions for calming dogs

1Vetoquinol Zylkene

Vetoquinol ZylkeneZylkene capsules come in a natural formula derived from casein, a protein in milk. Zylkene pills are palatable and easy to administer (once a day only).

These capsules from Zylkene are guaranteed lactose-free and preservative-free. The capsules can be opened and mixed with food or simply offered as a treat.

Correct doses are based on the weight of the dog. For best results, it is recommended that this best dog anxiety medication be administered several days before the expected anxiety stimuli. It is available in 75 mg, 225 mg, and 450mg. Users of this product attest to its efficacy in calming their pets.

Many professional trainers have used Zylkene for dog training and behavior modification. They claim that the supplement takes the edginess off the dog and speeds up the training process. Ageing dogs that had anxiety issues also benefited from this pill. Zylkene makes life more enjoyable for senior pets and their owners. Combined with daily training and exercises, this proved to be the solution for overly reactive dogs as well.

Not all dogs given Zylkene responded as positively as their owners would have expected. Some customers were quite disappointed that this best dog anxiety medication did not resolve their dogs’ fears. In some instances it even made a few dogs ill. The anxiety level of the dog must be assessed by a veterinarian, and be factored in to the dosing requirements.


  • Easy to administer
  • Natural formula
  • Lactose- and preservative-free
  • Only 1 dosage per day

  • May make dog sick
  • Doesn't always work

Best Dog Anxiety MedicationsMost helpful review (read full Amazon review): “I wanted to share that our 15 year old Mini Dachshund is using this instead of a regular anti-anxiety drug. He has heart issues so we had to find…”


2Particluar Paws Dog Calming Aid

Particluar Paws Dog Calming AidThis chewable Dog Calming Aid by Particular Paws is an all-natural product that contains five potent ingredients. They are passion flower, chamomile flower, thiamine mononitrate, ginger and L-tryptophan.

These ingredients combine to improve sleep and calm nerves. Dog Calming Aid also enhances stomach health, modifies mood positively, and provide vitamins and nourishment.

This formula is safe for dogs of all sizes, but not recommended for puppies under 12 weeks old. A bottle contains 60 nice-tasting chewable tablets. It can be bought without a prescription. Customers were pleasantly surprised to find quick results. In fact, it was effective in most pets within only a few hours of giving the pill. Pet owners don’t really want their dogs to become dependent on any regular or long-term medication. They generally feel most comfortable using the best dog anxiety medication that are all-natural.

The natural composition of the supplement is a very important factor to buyers. No pet owner would want their dogs drugged just to make them calmer. They found Dog Calming Aid perfect for short car trips and routine visits to the groomer and vet. Owners also noted that their dogs’ excessive barking and high-strung behaviors were significantly reduced.

Best Dog Anxiety Medication as Calming Medicine for DogsHowever, a few customers who gave this pill to their intensely anxious dogs observed no sign of calming. Even keeping the pill in the daily diet of the dogs for more than 2 weeks made no improvement whatsoever. Most of these dogs also didn’t like the smell and sight of the pill. It was an ordeal to get them to take it. For most cases this was a very effective, safe and convenient way to treat a dog's anxiety. Buying it also requires no prescription from the doctor, so that is another plus.


  • Chewable
  • All-natural
  • Safe for all sized breeds

  • Not for puppies under 12 weeks
  • Some dogs showed no change in behavior

best dog anxiety medicationsMost helpful review (read full Amazon review): “I have a very high-strung, Shih Tzu girl….and she has a terrible time with seperation anxiety, to the point that she tries to fight her way…”


3Dog Anxiety by Pet Relief

Dog Anxiety by Pet ReliefIf pills and chewables aren't working for your pet, Dog Anxiety Pet Relief solution could be your next option. This is one of the best dog anxiety medication! It is guaranteed 100% all-natural, safe and very effective in making your dog less hyperactive and fearful.

This dog anxiety medication made by Pet Relief is also very effective for overly anxious dogs who are triggered by various situations like going to the vet or the groomer and needs calming beforehand.

This spray is so easy to use! All you have to do is spray it on the dog’s paws and ears, and you’re good to go on your walks or travels. This affordable solution, which comes in a 30-ml spray bottle, will save you money too. It's much cheaper than many other treatment options. It is also covered by a lifetime warranty from the manufacturer.

Satisfied customers have been continually amazed by Dog Anxiety Pet Relief. Since this is applied by spraying externally, pet owners do away with ramming a pill down their pet’s throat. They even liked its scented smell and had no ‘oily’ issues to worry about.

Best Dog Anxiety Medication as Calming Medicine for DogsA few, on the contrary, disliked the strong scent. They complained that it left behind a distasteful smell. According to them, the spray didn’t have any effect on their pet despite several weeks of religiously using it on their dogs. The majority of the buyers, however, are satisfied customers and would-be repeat clients. They have seen their pets’ suffering for years and simply couldn’t believe that one of the best dog anxiety medication would solve their woes in a matter of minutes.


  • 100% all-natural
  • Easy to use spray
  • Affordable alternative to other anti-anxiety treatments

  • Poor smell

best dog anxiety medicationsMost helpful review (read full Amazon review). “Amazing. Literally a night and day difference. I have a 1 year old American bully with separation issues and I've tried everything. She's destroyed 3 metal crates, 1 plastic…”


4Bach Rescue Remedy

Bach Rescue RemedyRescue Remedy is definitely one of the best dog anxiety medication for stressed and high-strung dogs and cats. This is a homeopathic, alcohol-free solution. It helps dogs cope with separation anxiety, hyperactivity, traveling, noises, and social situations.

This solution from Bach is easy to administer as well. You simply place 4 drops of the solution on a food dish and another 4 drops into the drinking water. You could also apply some onto the dog’s belly.

The formula contains natural calming ingredients and pheromones, which create a sense of comfort and happiness. The calming effect stays for about 8 to 10 hours. A bottle contains 20 ml. This will allow you to treat your pet for months! There have been countless situations where a few drops of this solution have effectively calmed down pets in fight mode.

Dogs settled down and stopped their disruptive behavior after being applied with a few drops of Bach Rescue Remedy. This has been proven to be effective in acclimatizing dogs to new surroundings and people. Owners say it also helps their dogs overcome their immense fear and anxiety problems.

Other users observed that this worked for some of their pets but not for all their pets. They say that the solution is better used in conjunction with other treatments. They claim it is a good starting point for helping nervous pets mellow out. While buyers recognize the reasonability of the price, many would prefer a larger bottle.


  • Homeopathic
  • Alcohol-free
  • Easy to administer
  • Effects last 8-10 hours

  • Doesn't always work

best dog anxiety medicationsMost helpful review (read full Amazon review): “…I opened it on Saturday, put 4 drops on a milk bone biscuit. My husband laughed at me, he said it wouldn't work and I wasted my money. Boy…”


5Composure for Medium and Large Dogs

Composure for Medium and Large DogsA pack of Composure by VetriScience Laboratories contains 60 chewable supplements. This is another of the best dog anxiety medication available for anxious pets. It helps calm stress and behavioral issues in dogs.

Composure can be taken regularly without affecting your pet’s natural behavior. It contains vitamin B1 to reduce nervousness and confusion. L-theanine is also used to enhance relaxation without causing drowsiness.

Every pill is flavored with chicken liver to make it more palatable for dogs. The great thing about this product is its ability to calm hysterical dogs during heavy rains and thunderstorms without altering the dogs’ personality. Instead of whimpering and panicking during certain situations, they’re now playful and calm.

The pet owners are also happier to give Composure in place of sedation and other drug-based approaches with serious side effects. While many buyers have had success with this product, some were not as fortunate. They found no improvement in their dogs.

Best Dog Anxiety Medication as Calming Medicine for DogsSome owners called the formulation too weak for their dog’s condition. Others admitted to giving doses lower than what was recommended. Still, this is a very promising product which does not need a vet’s prescription. It also has no side effects and boasts the great possibility of saving a dog from becoming a nervous wreck.


  • Chewable
  • Not changing natural behavior
  • Does not cause drowsiness
  • Very tasty chews

  • Doesn't always work

best dog anxiety medicationsMost helpful review (read full Amazon review): “I have two dogs, one who becomes completely hysterical with thunderstorms, and mildly hysterical with heavy rain. My other dog takes on…”

10 Cheap Best Dog Anxiety Relief as Alternatives

The above list of five best dog anxiety medicine solutions are based off of pet owners' response in terms of what seems to be most effective for calming down a dog. However, some of the solutions may not work for all dogs or specific breeds, while other dog anxiety medication may be too expensive or not available at the moment.

I've done further research and below listed ten more alternatives for best anxiety relief for dogs, most of which have been positively reviewed by other dog owners as effective pills. Once again, remember to consult with your veterinarian before giving any meds to dogs.

6. Quiet Moments Calming Aid Plus MelatoninQuiet Moments Calming Aid Plus Melatonin
7. Vet's Best Comfort Calm Calming Dog Supplement
8. MaxxiCalm Calming Aid for Dogs
9. Pro-Sense Calming Tablets
10. HomeoPet Anxiety Relief
11. NaturVet Quiet Moments Calming Aid
12. Deley Naturals Dog Anxiety Support
13. Ultra Soothe Calming Aid for Dog Treats
14. Calming for Dogs Natural Behavior Support Formula
15. Pet Naturals of Vermont Calming for Dogs & Cats

The above list of best anxiety relief pills for dogs should provide pet owners with enough potential options on how to calm down a down if natural, non-medicated methods do not work. Please note that before you give your dog anxiety medications, you must consult with your veterinarian and decide whether it's truly necessary. 

Our list of best dog anxiety medication review in video form:

Disclosure: We may earn affiliate commissions at no cost to you from the links on this page. This did not affect our assessment of products. Read more here and find full disclosure here.